A study of more than 2.5 million Scottish adults who received the Oxford / AstraZeneca vaccine for the first time revealed that there is a risk of developing an autoimmune bleeding disorder known as immune thrombocytopenic purpura (PTI) due to such treatment.
The disease, considered life-threatening, could appear during the first 27 days after a subject has been inoculated with the anti-Covid-19 treatment, according to the research led by the Edinburgh University (Scotland).
Aziz Sheikh, professor and author of said study that was published on the portal “Nature Medicine”, clarified that he does not seek to discredit the treatment, however he showed that the incidence of ITP increased to 1.13 cases per 100,000 inhabitants and that this is part of one of the side effects triggered by the main dose of the biologic. This figure is equivalent to 11 new cases for every million doses.
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The researcher assured that the data provided must be interpreted in the “context of a clear benefit of the vaccine against the potential risks in which they develop Covid-19.”
For these purposes, Professor Escoses expressed, during a virtual conference, that vaccines that fight other diseases such as hepatitis B, measles and influenza produced more cases, 10 to 30 ITP events per one million doses supplied. In this context, Sheikh emphasized that serious risks, triggered by ChAdOx1, are very rare.
However, the results of Scottish adults inoculated between December 2020 and April 2021 with the AstraZeneca vial were that 57% reported adverse effects such as bleeding and vascular events. Some of them presented these discomforts with the administration of the vaccine Pfizer.
The UK Medicines and Health Products Regulatory Agency (MHRA) reported the existence of 209 reports, related to thrombocytopenia and thromboembolic events – two types of blood clots – from patients inoculated with the first dose, as well as from people who received the full treatment.
Chris Robertson, from the Scottish Health Service and co-author of the study, pointed out that cases of ITP occurred more frequently among people over 69 years of age who had suffered from heart disease such as ischemic heart disease and myocardial infarction, as well as pathology chronic, such as diabetes.
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Faced with these findings, the researchers insisted that the risk of adverse effects, such as a vaccination reaction, is much lower than the danger produced by the Covid-19 severe, especially in the most vulnerable groups.
“The main message (of this study) is that the risk of suffering one of these events is much lower with the vaccine than if you develop Covid-19,” Sheikh stressed.
Another study published in “Nature Medicine” demonstrated the effectiveness of the AstraZeneca vaccine. According to the data provided in the work, the biological one reduced the cases of the new coronavirus by 61%, and increased to 79%, after the application of the second dose.
What is the PTI?
This hematological disorder occurs as an autoimmune response, this means that the immune system mistakenly attacks the body. Its causes are related to the deficiency of the ADAMTS13 enzyme, which when it fails, produces small clots in the blood vessels, a decrease in platelets, and destruction of red blood cells, damaging the body.
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According to the Hematology Service of the “La fe” University Hospital, Valencia in SpainThis condition is called “purple” because of the pigment that the skin of patients who suffer from it adopts. This pathology is considered one of the diseases that must be treated as a medical emergency.